Take note: PPIs and emerging issues

by Kazeem Olalekan MRPharmS In August 2009 we reported a potential interaction between Proton pump inhibitors (PPI) and Clopidogrel. Subsequent to that report, Lancet concluded that PPI does not interfere with the clinical benefits of clopidogrel. The case frustrated me because in one week I was asking my GPs to review prescribing and in the […]

Clopidogrel and Proton Pump Inhibitors

We have just receive some indication from the manufacturers (Sanofi Aventis + Bristol-Myer Squibb ) that Clopidogrel-containing medicines and proton pump inhibitors (PPIs) ‘should be avoided unless absolutely necessary’. The preliminary studies indicate a cytochrome P450-type interaction. Clopidogrel is a pro-drug which is metabolised in the liver, partially by the cytochrome P450 complex. Hence any […]