by Kazeem Olalekan MRPharmS In August 2009 we reported a potential interaction between Proton pump inhibitors (PPI) and Clopidogrel. Subsequent to that report, Lancet concluded that PPI does not interfere with the clinical benefits of clopidogrel. The case frustrated me because in one week I was asking
Read more →We have just receive some indication from the manufacturers (Sanofi Aventis + Bristol-Myer Squibb ) that Clopidogrel-containing medicines and proton pump inhibitors (PPIs) ‘should be avoided unless absolutely necessary’. The preliminary studies indicate a cytochrome P450-type interaction. Clopidogrel is a pro-drug which is metabolised in the liver,
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