Drug Alert: Amoxicillin Sodium 1g, 250mg and 500mg Powder for Solution for Injection – NOT FOR neonates and infants below one year old

by Kazeem Olalekan MRPharmS The Medicines and Healthcare products Regulatory Agency has just issued a Class 4 Drug Safety Alert for Wockhardt UK Ltd – Amoxicillin Sodium 1g, 250mg and 500mg Powder for Solution for Injection. Alert details Drug alert number EL (14)A/09 in connection with the above products was issued on 9 July 2014. […]

A practical point – Picato: ingenol mebutate

by Kazeem Olalekan MRPharmS Pharmacognosy is the branch of knowledge concerned with medicinal drugs obtained from plants or other natural sources. This has been critical to drug development and exemplified by the recent ward of the Nobel prize for medicines to the Chinese scientist Youyou Tu (a pharmaceutical chemist) (link) who is famous for discovering […]

Febuxostat (Adenuric) and hypersensitivity reaction

by Kazeem Olalekan Attention has just been drawn to the Drug Safety Update on Febuxostat (Adenuric) via the PJOnline website. In summary, there have been rare but serious reports of hypersensitivity reactions, including Stevens-Johnson syndrome and acute anaphylactic shock, with febuxostat (Adenuric). Febuxostat must be stopped immediately if hypersensitivity occurs, and must not be re-started […]

Urgent: (Action Required within 5 days) – MHRA Class 3 Alert: Cyclizine Lactate Injection 50mg/ 1ml ampoules

by Kazeem Olalekan MRPharmS Cyclizine Lactate Injection 50mg/ 1ml ampoules PL 00156/0096 Martindale Pharmaceuticals Ltd is recalling all remaining unexpired ampoules of the above discontinued product as a precautionary measure. This is due to a GMP concern at a third-party supplier and their own site. It is likely that very little stock remains but Martindale Pharmaceuticals […]

Cloudy but clearly OK – MHRA Class 4 alert for Priadel Liquid

A class 4 alert has been issued for Priadel Liquid by the MHRA. Priadel Liquid (Lithium Citrate 520mg/5ml equivalent to Lithium Carbonate 204mg/5ml) appears cloudy rather than clear. A detailed investigation carried out by Sanofi, the manufacturer, “has shown that the cloudiness is not due to microbial contamination. The root cause has been attributed to […]

Take note: PPIs and emerging issues

by Kazeem Olalekan MRPharmS In August 2009 we reported a potential interaction between Proton pump inhibitors (PPI) and Clopidogrel. Subsequent to that report, Lancet concluded that PPI does not interfere with the clinical benefits of clopidogrel. The case frustrated me because in one week I was asking my GPs to review prescribing and in the […]

Class 1 Drug Alert Co-codamol by Wockhardt UK Ltd Batch: LL11701

A class 1 drug alert (FOR IMMEDIATE ACTION) was posted on the MHRA website last week for Co-codamol 8/500 (codeine phosphate 8mg, paracetamol 500mg) containing rogue Co-codamol 30/500 tablets! The brand affected was manufactured by Wockhardt UK Ltd. Batch No: LL11701.   Excerpts from the MHRA website below: Visit the MHRA website for more information

Safety Update: TEVA levothyroxine 100 microgram tablets

by Kazeem Olalekan A safety alert has come to our attention via the MHRA: Following a review by the Commission on Human Medicines (CHM), the marketing authorisation (licence) for levothyroxine 100 microgram tablets manufactured by Teva has been suspended. Teva levothyroxine 100 microgram tablets will cease to be available in the UK within the next […]

Product Recall–Sterimar (Batches: FE1248b; FE1249)

The Medicines and Healthcare products Regulatory Agency (MHRA) has received warning of possible bacterial contamination in batches of the saline nasal spray Sterimar Isotonic 100ml. The spray is sold online and at high street retailers and is commonly used to cleanse the nasal passage. As part of its regulatory requirement the manufacturer has informed the […]

Drug Safety Alert – Dronedarone

Dronedarone (Multaq▼) is an antiarrhythmic agent indicated in adult, clinically stable patients with history of, or current, non-permanent atrial fibrillation (AF) to prevent recurrence of AF or to lower ventricular rate. Dronedarone is available as a 400 mg film-coated tablet and the recommended dose is 400 mg twice daily. Dronederone was only approved by NICE […]

Class 3 Drug Alert: Novgos 3.6 mg Implant

Action within 5 days Genus Pharmaceuticals Ltd is temporarily ceasing manufacture of the above product and recalling all remaining stock from pharmacy and wholesaler level. This is due to a small number of problems during implantation and the product is being withdrawn until the implantation system can be made more robust. Product: Genus Pharmaceuticals Ltd […]

Class 2: Drug Alert – Gaviscon Advance

Gaviscon Advance Peppermint Flavour Oral suspension containing sodium alginate 500mg and potassium bicarbonate 100mg in 5ml PL 0063/0103 Batch Number Expiry Date Pack Size First Distributed 924471 1/08/2011 500 ml bottle 19/09/2009 925071 1/09/2011 500 ml bottle 19/09/2009 Reckitt Benckiser Healthcare (UK) Ltd are recalling the above lots due to a low -evel microbial contamination […]