What’s New? The BNF and BNFc updates

by Kazeem Olalekan A BNF and BNFc app convert like myself knows to press the ‘Update Now’ button whenever I am prompted to do so. It is the best way to be up-to-date in clinical decision making. What I thought I would do today is highlight some key updates in the BNF and BNFc in […]

Febuxostat (Adenuric) and hypersensitivity reaction

by Kazeem Olalekan Attention has just been drawn to the Drug Safety Update on Febuxostat (Adenuric) via the PJOnline website. In summary, there have been rare but serious reports of hypersensitivity reactions, including Stevens-Johnson syndrome and acute anaphylactic shock, with febuxostat (Adenuric). Febuxostat must be stopped immediately if hypersensitivity occurs, and must not be re-started […]

Urgent: (Action Required within 5 days) – MHRA Class 3 Alert: Cyclizine Lactate Injection 50mg/ 1ml ampoules

by Kazeem Olalekan MRPharmS Cyclizine Lactate Injection 50mg/ 1ml ampoules PL 00156/0096 Martindale Pharmaceuticals Ltd is recalling all remaining unexpired ampoules of the above discontinued product as a precautionary measure. This is due to a GMP concern at a third-party supplier and their own site. It is likely that very little stock remains but Martindale Pharmaceuticals […]

Cloudy but clearly OK – MHRA Class 4 alert for Priadel Liquid

A class 4 alert has been issued for Priadel Liquid by the MHRA. Priadel Liquid (Lithium Citrate 520mg/5ml equivalent to Lithium Carbonate 204mg/5ml) appears cloudy rather than clear. A detailed investigation carried out by Sanofi, the manufacturer, “has shown that the cloudiness is not due to microbial contamination. The root cause has been attributed to […]

Class 1 Drug Alert Co-codamol by Wockhardt UK Ltd Batch: LL11701

A class 1 drug alert (FOR IMMEDIATE ACTION) was posted on the MHRA website last week for Co-codamol 8/500 (codeine phosphate 8mg, paracetamol 500mg) containing rogue Co-codamol 30/500 tablets! The brand affected was manufactured by Wockhardt UK Ltd. Batch No: LL11701.   Excerpts from the MHRA website below: Visit the MHRA website for more information

Safety Update: ALTITUDE ‘unboost’

by Kazeem Olalekan MRPharmS Early result from the ALiskiren Trial In Type 2 diabetes Using cardiovascular and renal Disease Endpoints (ALTITUDE) study has shown that: study patients were unlikely to benefit from aliskiren; and an increased incidence of non-fatal strokes, renal complications (including acute renal failure), hyperkalaemia and hypotension in patients randomised to the aliskiren […]

Safety Update: TEVA levothyroxine 100 microgram tablets

by Kazeem Olalekan A safety alert has come to our attention via the MHRA: Following a review by the Commission on Human Medicines (CHM), the marketing authorisation (licence) for levothyroxine 100 microgram tablets manufactured by Teva has been suspended. Teva levothyroxine 100 microgram tablets will cease to be available in the UK within the next […]

Product Recall–Sterimar (Batches: FE1248b; FE1249)

The Medicines and Healthcare products Regulatory Agency (MHRA) has received warning of possible bacterial contamination in batches of the saline nasal spray Sterimar Isotonic 100ml. The spray is sold online and at high street retailers and is commonly used to cleanse the nasal passage. As part of its regulatory requirement the manufacturer has informed the […]

Odder than Odd!

by Kazeem Olalekan The discovery of blister packs of Seroquel XL (manufactured by AstraZeneca) and Neurontin 100mg capsules (manufactured by Pfizer) in Reckitt Benckiser’s Nurofen Plus OTC tablets is odder than odd (1)! As far as I can tell, these were not even manufactured in the same factory. Or arewere they? Reckitt Benckiser’s suspicion of […]

Pioglitazone: risk of bladder cancer

The MHRA has just posted a safety update that the use of pioglitazone is associated with a small increased risk of bladder cancer. Healthcare professionals should be aware of new warnings and precautions for use in at-risk patients. The advice for healthcare professionals include: Patients with active bladder cancer or with a history of bladder […]

You do the Crime…

Counterfeit medicine is a menace that must be stopped. Mike Deats, MHRA Head of Enforcement was quoted recently as saying “The MHRA will not hesitate to take action against those who undermine public health.” This follows the successful prosecution of Graham Dawson, the mastermind behind a scam of conspiracy to supply counterfeit medicines. He received […]